If you miss a dose of ACIPHEX, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your normal schedule. Do not take 2 doses at the same time. Its demethylated-metabolite was also positive in the Ames test. Sea buckthorn contains vitamins A, B1, B2, B6, C, and other active ingredients. purchase erythromycin generico
The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. Narcotic opioid medication can interact with many other drugs and cause dangerous side effects or death. Take a missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and go back to the normal schedule. Do not take two doses at the same time. Ye, L. M. Intra-herb pharmacokinetics interaction between quercetin and isorhamentin. Acta Pharmacol. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.
See in prescribing information for amoxicillin. Williams, H. C. Dietary supplements for established atopic eczema. Cochrane. Compared to other biologic therapies, Prolia has a relatively moderate price.
Steinbeck G, Reichart B, Kaczmarek I. Proton pump inhibitors reduce mycophenolate exposure in heart transplant recipients-a prospective case-controlled study. Dexilant delayed-release capsules may increase the risk of hip, wrist, and spine fractures in patients with weak bones osteoporosis. The risk may be greater if you use Dexilant delayed-release capsules in high doses or for longer than a year, or if you are older than 50 years old. Contact your doctor if you have any questions about this information. Togashi, H. Effects of a herbal medicine, Hippophae rhamnoides, on cardiovascular functions and coronary microvessels in the spontaneously hypertensive stroke-prone rat. Clin.
B-12 caused by hypo-or achlorhydria. Rare reports of cyanocobalamin deficiency occurring with acid-suppressing therapy have been reported in the literature. This diagnosis should be considered if clinical symptoms consistent with cyanocobalamin deficiency are observed in patients treated with ACIPHEX. How should I take rabeprazole Aciphex? The most commonly reported side effects are headache, diarrhea, and abdominal pain. Do not consider Communities as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Rabeprazole is in a group of drugs called proton pump inhibitors. Rabeprazole decreases the amount of acid produced in the stomach. Kallio, H. Postprandial hyperglycemia and insulin response are affected by sea buckthorn Hippophae rhamnoides ssp. turkestanica berry and its ethanol-soluble metabolites. Eur. Ji, G. Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Aciphex may affect how other medicines work, and other medicines may affect how Aciphex works. LOX-1 and eNOS expression. Take the mixture within 15 minutes. Swallow the mixture without chewing. Do not save it for later use. Saggu, S. and Kumar, R. Effect of seabuckthorn Hippophae rhamnoides leaf aqueous and ethanol extracts on avoidance learning during stressful endurance performance of rats: a dose dependent study. Phytother. Mycophenolate mofetil MMF: Co-administration of PPIs in healthy subjects and in transplant patients receiving MMF has been reported to reduce the exposure to the active metabolite, mycophenolic acid MPA possibly due to a decrease in MMF solubility at an increased gastric pH. The clinical relevance of reduced MPA exposure on organ rejection has not been established in transplant patients receiving PPIs and MMF. Use ACIPHEX Sprinkle with caution in transplant patients receiving MMF. Dexilant delayed-release capsules comes with an extra patient information sheet called a Medication Guide. It also comes with instructions for use. Read them carefully. Read them again each time you get Dexilant delayed-release capsules refilled. For many of them -- at least 50% according to some research -- nighttime heartburn is a special problem. Since lying flat can aggravate the symptoms, trying to can be painful and difficult. There can also be more serious long-term consequences. Studies show that nighttime heartburn increases the risk of developing other serious conditions, including of the esophagus. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. The remainder of the dose was recovered in the feces.
Hepatic encephalopathy occurred in patients with underlying cirrhosis. ACIPHEX delayed-release tablets when compared to 10 healthy subjects. How should I take ACIPHEX? Always check your bottle to make sure you have received the correct pills same brand and type of medicine prescribed by your doctor. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy. The median fasting gastrin level increased in a dose-related manner in patients treated once daily with ACIPHEX delayed-release tablets for up to eight weeks for ulcerative or erosive esophagitis and in patients treated for up to 52 weeks to prevent recurrence of disease. Tell your doctor if your condition persists or worsens. The risk of side effects goes up over time. Ask your doctor how long you should take this medication. ACIPHEX delayed-release tablets are provided in one strength, 20 mg. The tablets are round, light yellow, enteric coated, biconvex tablets. “ACIPHEX 20” is imprinted in red on one side of the tablet. After seven days of treatment, Gilard and colleagues found that patients who took Plavix plus Prilosec were more than four times more likely to be "poor responders" to Plavix than were those who received Plavix alone. azulfidine
Contact your doctor if you have any symptoms of a bleeding ulcer, such as black, tarry stools or vomit that looks like coffee grounds; or if you experience throat pain, chest pain, severe stomach pain, or trouble swallowing. Swallow the delayed-release tablet whole. Do not crush, chew, or split the tablet. You may take this medicine with or without food. If your doctor tells you to take the medicine with food, follow those instructions. Healthcare professionals sometimes prescribe Aciphex for off-label to treat functional dyspepsia, a condition that causes upset stomach and pain in the upper abdomen. Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. Zeb A. Chemical and nutritional constituents of sea buckthorn. Aciphex. Call your doctor if you have a decrease in the amount that you urinate or if you have blood in your urine. Some of the side effects that can occur with rabeprazole may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. Influence of lansoprazole and rabeprazole on mycophenolic acid pharmacokinetics one year after renal transplantation. Your doctor may prescribe antibiotic medicines with Aciphex to help treat a stomach infection and heal stomach duodenal ulcers that are caused by bacteria called H. pylori. The condition causes heartburn and can damage the esophagus. Includes only patients with pretreatment and post-treatment clarithromycin susceptibility test results. Patients should use the lowest dose and shortest duration of PPI therapy appropriate to the condition being treated. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Aciphex for a condition for which it was not prescribed. Do not give Aciphex to other people, even if they have the same symptoms that you have. It may harm them. nimotop store in dubai nimotop
GERD and were randomized to either 10 mg or 20 mg once daily for up to 8 weeks for the evaluation of safety and efficacy. The adverse reaction profile in adolescent patients was similar to that of adults. The information contained in the Truven Health Micromedex products as delivered by Drugs. Aciphex delayed-release tablets and instructions for preventing or managing them. For a hypersecretory condition, such as Zollinger-Ellison syndrome, the dose for an adult generally starts with 60 mg of Aciphex daily, though the dosage can be adjusted as necessary. If you have any questions about Dexilant delayed-release capsules, please talk with your doctor, pharmacist, or other health care provider. Effect of omeprazole on the steady-state pharmacokinetics of voriconazole. rabeprazole buy now visa canada
Bone fractures. People who take multiple daily doses of PPI medicines for a long period of time 1 year or longer may have an increased risk of fractures of the hip, wrist, or spine. You should take ACIPHEX exactly as prescribed, at the lowest dose possible for your treatment and for the shortest time needed. Store at room temperature away from moisture, heat, and light. Your child should take the entire dose within 15 minutes. Spechler says, "unless the condition is especially severe, or there's some very compelling reason why a person shouldn't take medicine, I don't see any reason to torture patients with very tight dietary restrictions or elevating the head of the bed. You should tell your doctor if you are pregnant or might become pregnant before taking this medicine. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Aciphex while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use Aciphex, check with your doctor. Discuss any possible risks to your baby. This list is not complete and other drugs may interact with rabeprazole. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Guarnieri J. Effect of food and gastric acidity on absorption of orally administered ketoconazole. Lazar JD, Wilner KD. Drug interactions with fluconazole. idba.info prandin
This medication may interfere with certain laboratory tests, possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug. The two studies randomized 209 and 285 patients, respectively, to receive either 10 mg or 20 mg of ACIPHEX delayed-release tablets once daily or placebo. As demonstrated in Tables 10 and 11 below, patients treated with ACIPHEX delayed-release tablets were significantly superior to placebo in both studies with respect to the maintenance of healing of GERD and the proportions of patients remaining free of heartburn symptoms at 52 weeks. The recommended dosage of ACIPHEX delayed-release tablets is 20 mg once daily. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. How should I store ACIPHEX Sprinkle? Aciphex for over 2 years now after having had a scope done to re-enlarge my esophagus from GERD making it slowly close over many years. I have tried every OTC out there and nothing works as well if at all like this Med. Besides my co-pay doubling this year, which is hard to take, this medicine seems to be the only one that relieves all my symptoms. EE. It is not known if ACIPHEX is safe and effective if used longer than 12 months 1 year. Because Gilard and colleagues did not test patients for Plavix response before treating them, Gurbel says there is no way to know whether their poor response to the anticlotting drug was a result of PPI treatment. Eventually, I went to see my doctor, who basically said OTC acid reducers are my best bet. So I've been taking Omeprazole daily for over 18 months. For all other indications Aciphex delayed-release tablets can be taken with or without food. Take Aciphex exactly as prescribed. Your doctor will prescribe the dose that is right for you and your medical condition. Do not change your dose or stop taking Aciphex unless you talk to your doctor. Take Aciphex for as long as it is prescribed even if you feel better. The median fasting gastrin level increased in a dose-related manner in patients treated once daily with Aciphex delayed-release tablets for up to eight weeks for ulcerative or erosive esophagitis and in patients treated for up to 52 weeks to prevent recurrence of disease. The group median values stayed within the normal range. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. Check with your doctor to see whether you should take a calcium and vitamin D supplement while you use Aciphex. Check with your doctor right away if you have a decrease in how much or how often you urinate, bloody or cloudy urine, swelling of the feet or lower legs, rash, or a fever. These may be symptoms of a serious kidney problem. In clinical trials using combination therapy with rabeprazole plus amoxicillin and clarithromycin RAC no adverse reactions unique to this drug combination were observed. Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions.
Kees F, Faerber L. Bioavailability of mycophenolate mofetil and enteric-coated mycophenolate sodium is differentially affected by pantoprazole in healthy volunteers. You should not use this medication if you are allergic to rabeprazole or to similar medicines such as lansoprazole Prevacid esomeprazole Nexium omeprazole Prilosec, Zegerid or pantoprazole Protonix. Swallow Aciphex delayed-release tablets whole. Do not chew, crush or split the tablets. These increases were not statistically significant. Continue to take Dexilant delayed-release capsules even if you feel well. Do not miss any doses. In analyses adjusted for body mass and height, rabeprazole pharmacokinetics showed no clinically significant differences between male and female subjects. Tell your doctor or dentist that you take Aciphex before you receive any medical or dental care, emergency care, or surgery. PPI therapy appropriate to the condition being treated. Your antifungal medicine is absorbed the best in an acidic environment. Your other medicine decreases the amount of acid in your stomach. Aciphex and any potential adverse effects on the breastfed infant from Aciphex or from the underlying maternal condition. Use with caution. May make these conditions worse. Day or night, chronic reflux can gradually damage the esophagus. It may lead to inflammation and scar tissue that narrows the esophagus. Food and Drug Administration. According to the American Gastroenterological Association, 25 million people have every day. mircette online purchase
Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with oxymorphone. Your doctor may stop ACIPHEX if these symptoms happen. Use Dexilant delayed-release capsules with caution in the ELDERLY; they may be more sensitive to its effects, especially hip, wrist, and spine fractures. Several published observational studies in adults suggest that PPI therapy may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist, or spine. The risk of fracture was increased in patients who received high-dose, defined as multiple daily doses, and long-term PPI therapy a year or longer. Patients should use the lowest dose and shortest duration of PPI therapy appropriate to the condition being treated. Aciphex may increase the risk of hip, wrist, and spine fractures in patients with weak bones osteoporosis. The risk may be greater if you use Aciphex in high doses, for long periods of time, or if you are older than 50 years old. Contact your doctor if you have any questions about this information. If you miss a dose of Dexilant delayed-release capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. ACIPHEX Sprinkle may be considered in some patients receiving high dose methotrexate administration. Kumar, R. Adaptogenic and safety evaluation of seabuckthorn Hippophae rhamnoides leaf extract: a dose dependent study. H2 blockers, such as famotidine Pepcid AC and ranitidine Zantac 75. H2 blockers decrease acid production. They are available both over the counter and by prescription. protonix online jersey
Gastroesophageal Reflux Disease GERD. Dexilant delayed-release capsules may increase the risk of a serious form of diarrhea. Contact your doctor right away if stomach pain or cramps, severe or persistent diarrhea, or bloody or watery stools occur. Discuss any questions or concerns with your doctor. Zhang XJ, Zhang MS Wang JL et al. Effects of total flavones of Hippopphae Rhamnoides L TFH on pituitary gland. In patients with and moderate to severe esophageal acid exposure, a dose of 20 mg and 40 mg per day of ACIPHEX delayed-release tablets decreased 24-hour esophageal acid exposure. Does Aciphex oral have side effects? What should I avoid while taking rabeprazole Aciphex? For information about contraindications of antibacterial agents clarithromycin and amoxicillin indicated in combination with Aciphex delayed-release tablets, refer to the Contraindications section of their package inserts. Komiya, T. Isolation of five types of flavonol from seabuckthorn Hippophae rhamnoides and induction of apoptosis by some of the flavonols in human promyelotic leukemia HL-60 cells. Int J Mol. For Helicobacter pylori eradication take Aciphex delayed-release tablets with food. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. See Contraindications. May alter absorption of pH-dependent drugs eg, iron, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole, itraconazole. May antagonize atazanavir, nelfinavir avoid. May potentiate saquinavir, digoxin, methotrexate consider temporary withdrawal of the PPI; monitor. Caution with digoxin or drugs that may cause hypomagnesemia eg, diuretics; monitor. Monitor warfarin. Dave White, who has suffered from nighttime heartburn for years. For severe GERD, Spechler says that you may need not only one to two daily doses of a proton pump inhibitor, but also a dose of an H2 receptor antagonist. You may need over-the-counter antacids, too. In some cases, your doctor may recommend surgery to correct the problem that's causing your symptoms. But surgery isn't always a complete solution. Some people still wind up needing medication afterwards. Be sure you're under a doctor's care if you take heartburn drugs regularly. The pharmacokinetics of rabeprazole was studied in 12 adolescent patients with GERD 12 to 16 years of age, in a multicenter study. Patients received 20 mg Aciphex delayed-release tablets once daily for five or seven days. An approximate 40% increase in rabeprazole exposure was noted following 5 to 7 days of dosing compared with the exposure after 1 day dosing. Pharmacokinetic parameters in adolescent patients with GERD 12 to 16 years of age were within the range observed in healthy adult subjects. tegretol
Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. It would also state that rebound acid reflux, an increase in stomach acid, may also occur when you stop taking the drug after prolonged use. Faerber L. Omeprazole Impairs the Absorption of Mycophenolate Mofetil But Not of Enteric-Coated Mycophenolate Sodium in Healthy Volunteers. Aciphex may help your acid-related symptoms, but you could still have serious stomach problems. Talk with your doctor. Store at room temperature away from moisture and heat. Depending on the cause of the gastritis, additional measures or treatments may be needed. For example, if gastritis is caused by prolonged use of NSAIDs, a doctor may advise a person to stop taking NSAIDs, reduce the dose of NSAIDs, or switch to another class of medications for pain. PPIs may be used to prevent stress gastritis in critically ill patients. For Helicobacter pylori eradication take ACIPHEX delayed-release tablets with food. Gilard and colleagues report their findings in the Jan. 22 issue of the Journal of the American College of Cardiology. An editorial by Paul A. Gurbel, MD, director of the Sinai Center for Thrombosis Research and associate professor of medicine at Johns Hopkins University accompanies the Gilard report. Studies in juvenile and young adult rats and dogs were performed. In juvenile animal studies rabeprazole sodium was administered orally to rats for up to 5 weeks and to dogs for up to 13 weeks, each commencing on Day 7 post-partum and followed by a 13-week recovery period. This list is not complete. Other drugs may interact with oxymorphone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Use Aciphex as directed by your doctor. Check the label on the medicine for exact dosing instructions. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use ACIPHEX for a condition for which it was not prescribed. Do not give ACIPHEX to other people, even if they have the same symptoms that you have. It may harm them. Aciphex rabeprazole belongs to a class of drugs called proton pump inhibitors PPIs that decreases the amount of acid produced in the stomach. It is used to treat symptoms of gastroesophageal reflux disease GERD and conditions involving excessive stomach acid. Aciphex can also be used to promote healing of erosive esophagitis damage to your esophagus caused by stomach acid and to prevent gastric ulcer. Common side effects of Aciphex include headache, upset stomach, gas, constipation, diarrhea, insomnia, and nervousness. This is not a complete list of side effects that can occur with Aciphex. The safety record of PPIs is very good. These drugs have been around for over 20 years and some are available for use over-the-counter. However, there are some long-term effects to consider and a vitamin B12 deficiency is one of them. Vitamin B12 needs a protein called intrinsic factor in order to be absorbed from the digestive tract. Intrinsic factor is made by the stomach cells and this production is blocked by PPIs. So, over time, people taking PPIs can develop problems related to a vitamin B12 deficiency. It is reasonable to have the level checked on an annual physical exam and any time there are symptoms of a possible deficiency. These symptoms include weakness, tiredness, and shortness of breath. Other long-term effects of PPIs include calcium deficiency and a possible increased risk of hip, wrist, and spine fractures. Calcium requires stomach acid in order to be absorbed. So, after years of PPI use, it may be necessary to take a calcium supplement. This may also contribute to the increased risk of fractures. There may also be other causes of this increased risk, but it is not clearly understood at this point. Experts believe that PPIs may affect the normal turnover of bone. More studies are needed to help us understand this possible risk. Because the conditions that PPIs treat can themselves lead to serious outcomes, it is important to continue taking your PPI. Talk to your doctor about the long-term effects of PPIs and any concerns you may have. Do not stop or change the amount of medication you take without talking to your doctor first. Your doctor is best able to properly evaluate your risks and make recommendations based on your specific circumstances. The dosage and length of treatment are based on your medical condition and response to treatment. In children, the dosage is also based on weight. Diarrhea. ACIPHEX may increase your risk of getting severe diarrhea. This diarrhea may be caused by an infection Clostridium difficile in your intestines. Mycophenolate mofetil MMF: Co-administration of PPIs in healthy subjects and in transplant patients receiving MMF has been reported to reduce the exposure to the active metabolite, mycophenolic acid MPA possibly due to a decrease in MMF solubility at an increased gastric pH. The clinical relevance of reduced MPA exposure on organ rejection has not been established in transplant patients receiving PPIs and MMF. Use Aciphex delayed-release tablets with caution in transplant patients receiving MMF. eutirox
Xu WH, Chen J Deng ZT. Comparison between the total flavones of Hippopphae Rhamnoides L TFH and captopril on anti-hypertensive effects. China General Medicine. Rabeprazole may also be used for purposes not listed in this medication guide. Aciphex is excreted in rat milk, but it's not known if the same is true for human breast milk. Take ACIPHEX exactly as prescribed. Your doctor will prescribe the dose that is right for you and your medical condition. Do not change your dose or stop taking ACIPHEX unless you talk to your doctor. Take ACIPHEX for as long as it is prescribed even if you feel better. Your pharmacist can provide more information about rabeprazole.
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See “What is the most important information I should know about Aciphex? Larmo PS, Jarvinen RL, Setala NL, et al. Oral sea buckthorn oil attenuates tear film osmolarity and symptoms in individuals with dry eye. It may harm them. Rath, P. C. Chemoprevention by Hippophae rhamnoides: effects on tumorigenesis, phase II and antioxidant enzymes, and IRF-1 transcription factor. Nutr.
Sea buckthorn is an herb. The leaves, flowers, and fruits are used to make medicine. In 2014, Public Citizen filed a lawsuit against the FDA for its failure to respond to the petition. AUC values approximately doubled and the C max increased by 60% compared to values in a parallel younger control group. In adults, symptomatic response to therapy with ACIPHEX does not preclude the presence of gastric malignancy. Consider additional follow-up and diagnostic testing in adult patients who have a suboptimal response or an early symptomatic relapse after completing treatment with a PPI.
Aciphex delayed-release tablets are indicated for short-term up to four weeks treatment in the healing and symptomatic relief of duodenal ulcers. Most patients heal within four weeks. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Weight loss. Early evidence shows that taking sea buckthorn berries, berry oil, or extract by mouth does not reduce body weight in overweight or obese women. Zeb, A. Anticarcinogenic potential of lipids from Hippophae--evidence from the recent literature. Asian Pac.
Normally, the body constantly breaks down and rebuilds bone. Low in postmenopausal women unbalance this process in favor of bone breakdown. All medicines may cause side effects, but many people have no, or minor, side effects. Some MEDICINES MAY INTERACT with Dexilant delayed-release capsules. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue; unusual hoarseness; bloody or watery stools; bone pain; calf or leg pain, swelling, redness, or tenderness; chest, jaw, or arm pain; depression; fainting; fast, slow, or irregular heartbeat; fever, chills, or sore throat; joint pain, tenderness, swelling, or warmth; red, swollen, blistered, or peeling skin; seizures; severe or persistent diarrhea or stomach pain; severe or persistent nausea or vomiting; shortness of breath; stomach cramps; sudden, severe nausea or vomiting; symptoms of kidney problems eg, not able to pass urine, change in the amount of urine produced, blood in the urine, a big weight gain; symptoms of liver problems eg, dark urine, loss of appetite, pale stools, unusual nausea, yellowing of the skin or eyes; unexplained weight loss; unusual sweating; unusual tiredness or weakness.